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Pyroptosis and stroke

TANG Biao, DENG Chang-Qing^*

Medical School, Hunan University of Chinese Medicine, Changsha 410028, China

Abstract

Pyroptosis is a form of inflammatory programmed cell death activated by caspase-1 and caspase-4/5/11, and involves in the pathogenesis of infectious diseases and nervous system diseases. Pyroptosis is mediated by canonical inflammasome pathway and non-canonical inflammasome pathway. The canonical inflammasome pathway is activated in stroke and aggravates brain injury. Inhibition of inflammasome, caspase-1, IL-1β and IL-18 ameliorates brain injury. These studies indicate that canonical inflammasome pathway contributes to post-stroke brain injury, therefore, pyroptosis has become a potential therapeutic target for preventing excessive cell death during stroke. We reviewed the relationship between pyroptosis and stroke to provide some perspectives on future researches in this field.

Key words: pyroptosis;;

Received: 2017-09-20　　Accepted: 2017-12-25

Corresponding author: 邓常清　　E-mail: dchangq@sohu.com

DOI: 10.13294/j.aps.2017.0091

Citing This Article：

TANG Biao, DENG Chang-Qing. Pyroptosis and stroke. Acta Physiol Sin 2018; 70 (1): 93-98 (in Chinese with English abstract).