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Advances in neurobiological mechanisms of comorbid depression and gastro- intestinal disease

Zhang Tao^1,2, LINGHU Ting^1,2,3, ZHANG Xiao^1,2,3, TIAN Jun-Sheng^1,2,*, QIN Xue-Mei^1,2

¹Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China；²Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China；³College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China

Abstract

Depression is a common mood disorder, which is harmful to public health critically. Gastrointestinal diseases are a series of diseases with both dynamic changes and organic disease, including functional gastrointestinal disease, gastroesophageal reflux disease, gastritis, and gastric ulcer. In recent years, the phenomena of comorbid depression and gastrointestinal disease have become common, however, most patients were diagnosed as unilateral depression or gastrointestinal disease in the clinical treatment process, resulting in delayed treatment or even invalid. The present review focuses on some of the clinical symptoms of comorbid depression and gastrointestinal disease, and begins to explore the possible pathogenesis, so as to find out the potential neurobiological pathways of comorbidity. Consequently, the more attention on comorbid depression and gastrointestinal disease will be paid, and the clinical and basic research of comorbidity and the drug development will be provided.

Key words: depression;;;;

Received: 2017-07-19　　Accepted: 2018-01-11

Corresponding author: 田俊生　　E-mail: jstian@sxu.edu.cn

DOI: 10.13294/j.aps.2018.0004

Citing This Article：

Zhang Tao, LINGHU Ting, ZHANG Xiao, TIAN Jun-Sheng, QIN Xue-Mei. Advances in neurobiological mechanisms of comorbid depression and gastro- intestinal disease. Acta Physiol Sin 2018; 70 (1): 71-78 (in Chinese with English abstract).