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Research progress in the modulating effect of high-density lipoprotein on neutrophil function

WANG Zhi-Zhou¹, XIANG Hong², XIA Shi-Lin³, SHANG Dong^1,*

¹The First Affiliated Hospital, Dalian Medical University, Dalian 116000, China；²College (Institute) of Integrative Medicine, Dalian Medical University, Dalian 116000, China；³Key Laboratory of Integrated Medicine Research for Surgery Severity Diseases of Liaoning Provincial Education Department, Dalian Medical University, Dalian 116000, China

Abstract

For a long period, studies about the modulating effect of high-density lipoprotein (HDL) on inflammatory cells mainly focus on cardiovascular diseases. In recent years, researchers have found the significant role of HDL in many other fields, such as diabetes, metabolic syndrome, chronic kidney disease, systemic inflammatory disease, autoimmune diseases and infectious diseases. Researches have shown that HDL can inhibit the function of activated neutrophil via disturbing the cytokine production, deformation, adhesion, transmigration and pathogen elimination. Clinical trials have discovered that serum HDL level is negatively correlated with neutrophil-to-lymphocyte ratio in healthy males with low HDL level. In addition, serum HDL level is closely associated with disease severity of severe acute pancreatitis. Consequently, understanding the effect and mechanism of the regulation of HDL on neutrophil function plays an important role in remedying the diseases resulted from excessively activated neutrophil.

Key words: high-density lipoprotein; apolipoprotein A-I ; neutrophil

Received: 2017-06-06　　Accepted: 2017-09-30

Corresponding author: 尚东　　E-mail: shangdong@dmu.edu.cn

DOI: 10.13294/j.aps.2017.0077

Citing This Article：

WANG Zhi-Zhou, XIANG Hong, XIA Shi-Lin, SHANG Dong. Research progress in the modulating effect of high-density lipoprotein on neutrophil function. Acta Physiol Sin 2017; 69 (6): 852-860 (in Chinese with English abstract).