Issue Archive

EFFECT OF ACUTE HYPOXIA ON BLOOD CATECHOLAMINE AND WHOLE BLOOD PLATELET AGGREGATION

LI XIN-BO , GUO XUE-QIN

(Department of Physiology, Shanghai Medical University, Shanghai 200032)

Abstract

Experiments were performed on 250- 300 g male Sprague- Dawley rats under
urethane (700 mg/kg) and a-chloralose (35 mg/kg) anesthesia. Plasma catecholamine concentration and the whole blood platelet aggregation were measured during normoxia，acute hypoxia，reoxygenation，acute hypoxia immediately after bilateral adrenalectomy and acute hypoxia at the end of 15 and 30 min after bilateral adrenalectomy. The plasma adrenaline concentration and the whole blood platelet aggregation increased markedly (P<0. 01)，while the plasma noradrenaline concentration tended to increase (P> 0. 05) during acute hypoxia. The plasma adrenaline concentration and the whole
blood platelet aggregation are capable of restoring to the normal level during reoxygenation. The plasma noradrenaline concentration did not change，while the plasmaadrenaline concentration and the whole blood platelet aggregation decreased significantly(P<0. 001 or 0. 05)during acute hypoxia for 15 min immediately after bilateral adrenalectomy.

Key words: Acute hypoxia;platelet aggregation;Catecholamine;Adrenaline; noradrenaline

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

LI XIN-BO , GUO XUE-QIN. EFFECT OF ACUTE HYPOXIA ON BLOOD CATECHOLAMINE AND WHOLE BLOOD PLATELET AGGREGATION. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).