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EFFECT OF MICROINJECTION OF NEUROTENSIN INTO HYPOTHALAMIC PARAVENTRICULAR NUCLEUS ON GASTRIC ACID SECRETION IN RATS

HAN XIAO-HUA, CHEN JIA-JIN, Chen Lei

(Department of Physiology, Qingdao Medical College, Qingdao 266021)

Abstract

Effects of microinjection of neurotensin (NT) into the hypothalamic paraventrictr lar nucleus (PVN) on gastric acid secretion were investigated in urethane-anesthetized rats. The results were as follows:NT microinjection into PVN produced a dose-deperr dent decrease in gastric acid output (GAO);this inhibitory effect of NT was completely blocked by icv pretreatment with the a-adrenergic receptor antagonist phentolamine or after bilateral cervical vagotomy，suggesting that the effect may be related with activation of a-adrenergic receptors in the nucleus and mediated by vagal nerves.

Key words: hypothalamic paraventricular nucleus;Neurotensin;Gastric acid secretion;Phentolamine;vagotomy

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Citing This Article：

HAN XIAO-HUA, CHEN JIA-JIN, Chen Lei. EFFECT OF MICROINJECTION OF NEUROTENSIN INTO HYPOTHALAMIC PARAVENTRICULAR NUCLEUS ON GASTRIC ACID SECRETION IN RATS. Acta Physiol Sin 1996; 48 (2): (in Chinese with English abstract).