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CHANGES IN THE CALCIUM CHANNELS IN RAT CARDIAC CELLS DURING SEPSIS

Yang Qing, TANG XIU, DONG LIN-WANG, TANG CHAD-SHU

(Institute of Cardiovascular Basic Research, Beijing Medial University, Beijing 100083)

Abstract

Changes in the number of calcium channels in two subcellular fractions，the sarcolemma and the light vesicle，of rat cardic cells were studied during sepsis. Sepsis was induced by cecal ligation and puncture (CLP).The results showed that some of the calcium channels in the light vesicle translocated to the sarcolemma during the early sepsis (9 h after CLP) while during the late sepsis(18 h after CLP).Some of these in the sate colemma translocated to the light vesicle. The mechanisms of redistribution of the calcrum channels in the sarcolemma and the light vesicle during sepsis was not associated to
the phosphorylation of the calcium channels by cAMP dependent protein kinase(PKA)，Cal+/calmodulin dependent protein kinase (PKM) and protein kinase C (PKC).Since S-adrenrgic recptors，muscarinic cholinergic receptors and Na+ /K+一ATPase were also redistributed during sepsis，it is suggested that the redistribution might be non-specific.

Key words: sepsis;cardiac sarcolemma;cardiac light vesicle; calcium channel

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Citing This Article：

Yang Qing, TANG XIU, DONG LIN-WANG, TANG CHAD-SHU. CHANGES IN THE CALCIUM CHANNELS IN RAT CARDIAC CELLS DURING SEPSIS. Acta Physiol Sin 1996; 48 (2): (in Chinese with English abstract).