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Attenuation of chronic stress-induced hippocampal damages following physical exercise

Ma Qiang, Wang Jing, Liu Hongtao, Chao Fuhuan

Institute of Health and Environmental Medicine,Academy of Military Medical Sciences.Tianjin 300050

Abstract

The long-term potentiation (LTP) in the hippocampal dentate gyrus and the plasma glucocorticoids level were observed in rats to study the effects of physical exercise on chronic stress-induced hippocampal damages. Eight-week spontaneous wheel running exercise could attenuate the suppression of LTP induced by 21-day restraint stress, and maintain the normal plasma glucocorticoids levels. It is suggested that long-term physical exercise may protect the hippocampus from stress-induced damages.

Key words: Exercise;;;;

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Citing This Article：

Ma Qiang, Wang Jing, Liu Hongtao, Chao Fuhuan. Attenuation of chronic stress-induced hippocampal damages following physical exercise. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).