Reduced nitric oxide in the rostral ventrolateral medulla enhances cardiac sympathetic afferent reflex in rats with chronic heart failure
Zhu Guoqing, Gao Xingya, Zhang Feng, Wang Wei
Department of Physiology,Nanjing Medical University.Nanjing 210029,Jiangsu；USA
Abstract
It was observed that (1) the responses of RSNA to stimulation were enhanced in rats with CHF; (2) MeTC (80 nmol) potentiated the responses of RSNA to stimulation in sham rats but not in rats with CHF; (3) SNAP (50 nmol) depressed the enhanced RSNA response to stimulation in CHF rats but had no effect in sham rats; and (4) MeTC increased the baseline RSNA and MAP only in sham rats, but SNAP inhibited the baseline RSNA and MAP in both sham and CHF rats. These results indicate that reductance of NO in the RVLM is involved in the augmentation of CSAR in CHF rats.
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Citing This Article：
Zhu Guoqing, Gao Xingya, Zhang Feng, Wang Wei. Reduced nitric oxide in the rostral ventrolateral medulla enhances cardiac sympathetic afferent reflex in rats with chronic heart failure. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).
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