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The role of nitric oxide in the angiotensin II-induced hypertrophy of cardiac myocytes

Zhan Changde, Wang Tinghuai, Pan Jingyun

Department of Physiology,Sun Yat-sen University of Medical Sciences.Guangzhou 510089,Guangdong；Department of Physiology,Sun Yat-Sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The results suggest that angiotensin II may induce hypertrophy of cultured neonatal rat cardiomyocytes. The effect of angiotensin II is mediated by receptors which are coupled with PTX-sensitive G protein and may be related to the decreased eNOS gene expression, NOS activity and NO production. Exogenous NO can prevent the hypertrophy of cardiomyocytes induced by angiotensin II.

Key words: Nitric oxide;Angiotensin Ⅱ;Hypertrophy of cardiac myocytes

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Citing This Article：

Zhan Changde, Wang Tinghuai, Pan Jingyun. The role of nitric oxide in the angiotensin II-induced hypertrophy of cardiac myocytes. Acta Physiol Sin 1999; 51 (6): (in Chinese with English abstract).