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Effect of intracerebroventricular neurotensin injection on blood pressure in rat

Zhang Xiaohui, Yin Guoxiang, Ni Hui

Department of Physiology,Nanjing Medical University.Nanjing 210029,Jiangsu

Abstract

Injection of neurotensin (NT) (10 and 20#mu#g/rat) into the lateral cerebroventricle (icv) could induce a rise or a drop of blood pressure and a slowing down of heart rate in urethane anaesthetized male rats (1.2g/kg). The central pressor and depressor response to NT could be respectively blocked by pretreatment with #alpha#_(1)-receptor blocker praxosin (1.5#mu#g/3#mu#l, icv) and M receptor blocker atropine (2.5#mu#g/3#mu#l, icv). No significant changes in central cardiovascular responses to NT were observed following pretreatment with either H_(1) receptor blocker chlorpheniramin (50#mu#g/3#mu#l, icv) or H_(2) receptor blocker cimetidine (250#mu#g/2#mu#l, icv).

Key words: Neurotensin;Blood pressure;Prazosin;Atropine;Intracerebroventricular injection

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Citing This Article：

Zhang Xiaohui, Yin Guoxiang, Ni Hui. Effect of intracerebroventricular neurotensin injection on blood pressure in rat. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).