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The effect of renal dopamine receptor blockade on natriuresis induced by volume expansion and intracerebroventricular injection of hypertonic saline in rabbits

Xu Yaojun, Fu Lei, Lin Maozhang

Department of Physiology, Dalian Medical University. Dalian 116027, Liaoning

Abstract

In the VE experiments, Hal group decreases the peak increase of U_(Na) V from control group of 65.0±15.0 to 19.0±5.5#mu#mol/min(P<0.02). In the ICHNa experiments, the peak increase of U_(Na)V in control and Hal groups were respectively 28.9±4.6 and 29.0±5.8#mu#mol/min(P>0.50). In the experiments of rabbits with intact renal dopamine receptor, the natriuresis induced by VE+ICHNa was significantly greater than those due to either inducing factor acting alone. Renal dopamine receptor blockade also significantly attenuated the natriuresis induced by VE+ICHNa. These results indicate that renal dopamine receptor blockade significantly attenuated the natriuresis induced by VE+ICHNa, but did not affect the response of ICHNa.

Key words: Natriuresis;Diuresis;Volume expansion;Intracerebroventricular injection; Hypertonic saline;Renal dooamine receptor

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Citing This Article：

Xu Yaojun, Fu Lei, Lin Maozhang. The effect of renal dopamine receptor blockade on natriuresis induced by volume expansion and intracerebroventricular injection of hypertonic saline in rabbits. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).