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Reduction of incidence of ischemia-reperfusion induced ventricular fibrillation by captopril

Zhang Min, Pan Jingyun, Zhu Xiaonan, Zhan Chengyang

Jiujiang Medical School, Jiangxi Province. Jiujiang, Jiangxi； China

Abstract

Regional myocardial ischemia was induced by ligation of the left coronary artery followed by reperfusion. In the ischemia reperfusion group, ventricular fibrillation during reperfusion took place in 78% of the hearts. In the group pretreated with captopril, the incidence of ventricular fibrillation decreased significantly(65.5％). In comparision with the ischemia reperfusion group, myocardial catecholamine content and 6-keto-PGF_(1#alpha#) of the captopril group were significantly increased(P<0.01)while thromboxane B_(2)(TxB_(2)/6-keto-PGF_(1#alpha#) were decreased (P<0.01). In Ang Ⅱ group, infusion of angiotensin Ⅱ reversed the protective effect of captopril and restored the incidence of ventricular fibrillation (85％), while myocardial catecholamine content was not different from the ischemia reperfusion group (P>0.05).

Key words: Captopril;Ischemia-reperfusion;Ventricular fibrillation;Catecholamine; Thromboxane B_(2);Prostacyclin

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Citing This Article：

Zhang Min, Pan Jingyun, Zhu Xiaonan, Zhan Chengyang. Reduction of incidence of ischemia-reperfusion induced ventricular fibrillation by captopril. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).