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The analgesia effect and plasma corticosterone reaction during stress in adult rats treated neonatally with monosodium glutamate

Chen Qiliang, Li Jinhua, Liu Huici, Gu Feng, Yin Qizhang

Department of Physiology, Suzhou Medical College. Suzhou,Jiangsu

Abstract

In the present investigation, it was found that the number B-END)-immunoreactive neurons of hypothalamic arcuate nucleus (ARC) in MSG-treated rats decreased by 60.7%. No significant differences in the baseline pain threshold and the baseline corticosterone(CS) level were observed between the MSG-treated group and the control group. After electrical foot shock for 30 min, the analgesia effect was decrease significantly in MSA-treated rats, while the CS levels of toth MSA-treated rats and control rats were increased remarked. The results suggest that the B_END neurons of ARC were involved in analgesia, but not in CS reaction during stress.

Key words: Monosodium glutamate;Hypothalamic arcuate nucleus;#beta#-endorphin immunoreactive cells;Stress analgesia;Plasma corticosterone

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Citing This Article：

Chen Qiliang, Li Jinhua, Liu Huici, Gu Feng, Yin Qizhang. The analgesia effect and plasma corticosterone reaction during stress in adult rats treated neonatally with monosodium glutamate. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).