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Effects of intracarotid injection of adenosine on respiration blood pressure and renal sympathetic nerve activity

Su Xin, Zhang Wanyu, He Ruirong

Inst. Bas. Med., Hebei Med. Coll.

Abstract

In response to intracarotid injections of adenosine, MAP decreased in a dose-dependent manner, while the frequency of respiration increases with litttle change in depth. Following carotid sinus denervation, intracarotid injection of adenosine still resulted in a decrease of MAP but with no changes in respiration. By adding adenosine to perfusate of the isolated carotid sinus, both MAP and HR decreased, but these effects could be abolished by inactivation of carotid body. MAP decreased and RSNA enhanced during perfusing adenosine into carotid sinus. These effects couldbe abolished by the section of sinus nerve or inactivation of CB. It is considered that adenosine is capable of activating CB, decreasing MAP and heart rate but with a concomitant increases in respiration and RSNA.

Key words: Adenosine;Carotid body;Mean arterial blood pressure;Heart rate;Respiration;Renal sympathetic nerve activity

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Citing This Article：

Su Xin, Zhang Wanyu, He Ruirong. Effects of intracarotid injection of adenosine on respiration blood pressure and renal sympathetic nerve activity. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).