脂质运载蛋白-2介导慢性疼痛和瘙痒的神经免疫机制
崔夏林, 孙世宇, 马君怡, 周国坤, 刘通*
南通大学特种医学研究院，南通 226019
摘要
脂质运载蛋白-2 (lipocalin 2, LCN2)是lipocalin超家族的一员，在多种细胞中表达和分泌，是甾体、脂多糖、铁和脂肪酸等亲脂小分子的转运蛋白。 LCN2 在疼痛调节中具有重要作用，尤其参与炎症性疼痛和神经病理性疼痛的发生与维持，其作用机制涉及神经炎症调控及神经元-胶质细胞交互作用的调节。LCN2 在瘙痒调控中也表现出显著效应，通过结合特定受体并激活下游信号通路，参与慢性瘙痒的诱发与持续过程。本文综述了LCN2 在慢性疼痛与瘙痒调控基础研究中的最新进展，并探讨了其作为治疗靶点的潜在价值，以期为开发新的治疗策略提供理论依据。
关键词： 脂质运载蛋白-2; 疼痛; 瘙痒; 胶质细胞; 铁代谢
Neuroimmune mechanisms of lipocalin 2 in mediating chronic pain and itch
CUI Xia-Lin, SUN Shi-Yu, MA Jun-Yi, ZHOU Guo-Kun, LIU Tong*
Institute of Special Environmental Medicine, Nantong University, Nantong 226019, China
Abstract
Lipocalin 2 (LCN2), a member of the lipocalin superfamily, is expressed and secreted by various cells and functions as a transport protein for lipophilic small molecules such as steroids, lipopolysaccharides, iron and fatty acids. LCN2 plays a significant role in pain modulation, particularly in the development and maintenance of inflammatory pain and chroni